| Uruguay - Reserve League | 2021/08/30 18:17 | Juventud De Las Piedras - Reserves v Defensor Sporting - Reserves | W | 0-1 |
| Uruguay - Reserve League | 2021/08/24 18:00 | Defensor Sporting - Reserves v Rampla Juniors - Reserves | D | 1-1 |
| Uruguay - Reserve League | 2021/08/02 18:00 | Defensor Sporting - Reserves v Juventud De Las Piedras - Reserves | D | 2-2 |
| Uruguay - Reserve League | 2020/11/03 18:00 | Boston River - Reserves v Defensor Sporting - Reserves | L | 2-1 |
| Uruguay - Reserve League | 2020/10/27 18:00 | Defensor Sporting - Reserves v Nacional de Montevideo - Reserves | L | 0-1 |
| Uruguay - Reserve League | 2020/10/06 18:00 | Liverpool Montevideo - Reserves v Defensor Sporting - Reserves | D | 1-1 |
| Uruguay - Reserve League | 2020/09/15 18:00 | Defensor Sporting - Reserves v Progreso - Reserves | W | 1-0 |
| Uruguay - Reserve League | 2020/09/01 18:00 | Defensor Sporting - Reserves v Torque - Reserves | W | 1-0 |