[18] St Etienne 2-1 Brest [12] 2022-04-16 15:00
Stadium: Stade Geoffroy Guichard Round: 32
Referee: Eric Wattellier Home Manager: Pascal Dupraz Away Manager: Michel Der Zakarian
Head to Head
| Frankrijk - Ligue 1 | 2021/12/01 18:00 | Brest v St Etienne | L | 1-0 |
| Frankrijk - Ligue 1 | 2021/04/24 11:00 | St Etienne v Brest | L | 1-2 |
| Frankrijk - Ligue 1 | 2020/11/21 16:00 | Brest v St Etienne | L | 4-1 |
| Frankrijk - Ligue 1 | 2020/02/16 16:00 | Brest v St Etienne | L | 3-2 |
| Frankrijk - Ligue 1 | 2019/08/18 13:00 | St Etienne v Brest | D | 1-1 |